Drug interactions
Desipramine + Osilodrostat
Severity: Moderate
Desipramine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia, bradycardia or underlying heart disease.
What this interaction means in plain words
Desipramine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and repeat it after starting or changing doses. Correct potassium and magnesium abnormalities and reassess the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Desipramine with Osilodrostat?
MediHelp rates the interaction as moderate. Desipramine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia, bradycardia or underlying heart disease.
How serious is the interaction between Desipramine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting or changing doses. Correct potassium and magnesium abnormalities and reassess the combination if the QTc becomes markedly prolonged.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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