Drug interactions
Desipramine + Osimertinib
Severity: Moderate
Desipramine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib and desipramine each have the potential to lengthen the QTc interval, so using them together may increase the chance of serious ventricular arrhythmia. Patients with electrolyte disturbances or cardiac disease are at greater risk.
What this interaction means in plain words
Desipramine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Perform periodic ECG monitoring and check potassium and magnesium, correcting any deficits. Consider an alternative antidepressant if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Desipramine with Osimertinib?
MediHelp rates the interaction as moderate. Desipramine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib and desipramine each have the potential to lengthen the QTc interval, so using them together may increase the chance of serious ventricular arrhythmia. Patients with electrolyte disturbances or cardiac disease are at greater risk.
How serious is the interaction between Desipramine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and check potassium and magnesium, correcting any deficits. Consider an alternative antidepressant if the QTc becomes significantly prolonged.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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