Drug interactions
Desipramine + Papaverine
Severity: Minor
Desipramine and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine has some CNS depressant effect and might add mildly to desipramine sedation, but there is little evidence of a meaningful interaction. Papaverine can also affect cardiac conduction at high doses.
What this interaction means in plain words
Desipramine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive CNS depression; the mechanism is not well established.
What to do
Awareness is usually sufficient. Monitor for drowsiness and for cardiac rhythm changes if papaverine is given parenterally.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Desipramine with Papaverine?
MediHelp rates the interaction as minor. Desipramine and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine has some CNS depressant effect and might add mildly to desipramine sedation, but there is little evidence of a meaningful interaction. Papaverine can also affect cardiac conduction at high doses.
How serious is the interaction between Desipramine and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Awareness is usually sufficient. Monitor for drowsiness and for cardiac rhythm changes if papaverine is given parenterally.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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