Drug interactions
Desipramine + Selinexor
Severity: Moderate
Desipramine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and desipramine can add sedation and cognitive impairment. The overlap may raise the risk of falls and impaired mentation.
What this interaction means in plain words
Desipramine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation and counsel patients about falls and driving. Reduce the dose of either drug or choose another antidepressant if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Desipramine with Selinexor?
MediHelp rates the interaction as moderate. Desipramine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and desipramine can add sedation and cognitive impairment. The overlap may raise the risk of falls and impaired mentation.
How serious is the interaction between Desipramine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation and counsel patients about falls and driving. Reduce the dose of either drug or choose another antidepressant if symptoms emerge.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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