Drug interactions
Desipramine + Solifenacin
Severity: Moderate
Desipramine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine has anticholinergic activity and can prolong the QT interval and conduction. With solifenacin, anticholinergic effects such as urinary retention, constipation, dry mouth and confusion may be increased, and QT risk may be additive.
What this interaction means in plain words
Desipramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive muscarinic blockade and additive QT prolongation.
What to do
Monitor for anticholinergic toxicity, particularly in older adults, and obtain an ECG if cardiac risk factors exist. Consider reducing doses or choosing a less anticholinergic alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Solifenacin?
MediHelp rates the interaction as moderate. Desipramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine has anticholinergic activity and can prolong the QT interval and conduction. With solifenacin, anticholinergic effects such as urinary retention, constipation, dry mouth and confusion may be increased, and QT risk may be additive.
How serious is the interaction between Desipramine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in older adults, and obtain an ECG if cardiac risk factors exist. Consider reducing doses or choosing a less anticholinergic alternative.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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