Drug interactions
Desipramine + Ziconotide
Severity: Moderate
Desipramine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide commonly causes dizziness, confusion and sedation, and a tricyclic may add to these CNS effects. Cognitive impairment from ziconotide can worsen with other CNS-active drugs.
What this interaction means in plain words
Desipramine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects.
What to do
Monitor for sedation, confusion and mood changes, and reduce the dose of one agent if impairment develops. Stop ziconotide if serious cognitive or psychiatric effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Desipramine with Ziconotide?
MediHelp rates the interaction as moderate. Desipramine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide commonly causes dizziness, confusion and sedation, and a tricyclic may add to these CNS effects. Cognitive impairment from ziconotide can worsen with other CNS-active drugs.
How serious is the interaction between Desipramine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and mood changes, and reduce the dose of one agent if impairment develops. Stop ziconotide if serious cognitive or psychiatric effects occur.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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