Drug interactions
Desogestrel-ethinyl estradiol + Fluconazole
Severity: Minor
Desogestrel-ethinyl estradiol and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise ethinyl estradiol exposure modestly. This may increase estrogen-related adverse effects such as nausea, breast tenderness or headache, though contraceptive efficacy is not reduced.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 (and related enzymes), reducing the metabolism of ethinyl estradiol.
What to do
No routine change is needed; ask the patient about estrogenic adverse effects during prolonged fluconazole courses and review the contraceptive if they are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Fluconazole?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole can raise ethinyl estradiol exposure modestly. This may increase estrogen-related adverse effects such as nausea, breast tenderness or headache, though contraceptive efficacy is not reduced.
How serious is the interaction between Desogestrel-ethinyl estradiol and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; ask the patient about estrogenic adverse effects during prolonged fluconazole courses and review the contraceptive if they are troublesome.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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