Drug interactions
Desogestrel-ethinyl estradiol + Idelalisib
Severity: Moderate
Desogestrel-ethinyl estradiol and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib strongly inhibits CYP3A and may raise ethinyl estradiol and progestin exposure. This could increase estrogen-related adverse effects such as nausea, breast tenderness and thromboembolic risk.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by idelalisib reduces the metabolism of ethinyl estradiol and the progestin.
What to do
Monitor for estrogen excess effects and thromboembolic symptoms, and consider a lower-dose or non-hormonal contraceptive if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Idelalisib?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib strongly inhibits CYP3A and may raise ethinyl estradiol and progestin exposure. This could increase estrogen-related adverse effects such as nausea, breast tenderness and thromboembolic risk.
How serious is the interaction between Desogestrel-ethinyl estradiol and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess effects and thromboembolic symptoms, and consider a lower-dose or non-hormonal contraceptive if adverse effects appear.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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