Drug interactions
Desogestrel-ethinyl estradiol + Oteseconazole
Severity: Minor
Desogestrel-ethinyl estradiol and Oteseconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and may increase ethinyl estradiol exposure. The clinical relevance is uncertain, though higher estrogen exposure could increase estrogenic adverse effects.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Oteseconazole belongs to Anti Fungals.
Why it happens
BCRP inhibition by oteseconazole reduces efflux of ethinyl estradiol.
What to do
Monitor for estrogen-related adverse effects during treatment. Further action is rarely needed, but note oteseconazole has a very long half-life.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glibenclamide + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Oteseconazole?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oteseconazole inhibits BCRP and may increase ethinyl estradiol exposure. The clinical relevance is uncertain, though higher estrogen exposure could increase estrogenic adverse effects.
How serious is the interaction between Desogestrel-ethinyl estradiol and Oteseconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects during treatment. Further action is rarely needed, but note oteseconazole has a very long half-life.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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