Drug interactions
Desogestrel-ethinyl estradiol + Ranolazine
Severity: Minor
Desogestrel-ethinyl estradiol and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and may modestly raise ranolazine concentrations. Ranolazine prolongs the QT interval in a dose-related fashion, so higher exposure could increase adverse effects.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated ranolazine metabolism by ethinyl estradiol.
What to do
Usually no dose change is needed; monitor for dizziness, nausea and QT prolongation if ranolazine is at high dose or other risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Ranolazine?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and may modestly raise ranolazine concentrations. Ranolazine prolongs the QT interval in a dose-related fashion, so higher exposure could increase adverse effects.
How serious is the interaction between Desogestrel-ethinyl estradiol and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed; monitor for dizziness, nausea and QT prolongation if ranolazine is at high dose or other risk factors exist.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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