Drug interactions
Desogestrel-ethinyl estradiol + Rucaparib
Severity: Minor
Desogestrel-ethinyl estradiol and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19, which converts desogestrel to its active form and also contributes to other steroid metabolism. The clinical effect on contraceptive hormone exposure is uncertain and likely small.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C19 and may alter hormone metabolism.
What to do
No routine change needed. Monitor for changes in bleeding pattern or hormonal adverse effects, and counsel that rucaparib is hazardous in pregnancy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Rucaparib?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C19, which converts desogestrel to its active form and also contributes to other steroid metabolism. The clinical effect on contraceptive hormone exposure is uncertain and likely small.
How serious is the interaction between Desogestrel-ethinyl estradiol and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Monitor for changes in bleeding pattern or hormonal adverse effects, and counsel that rucaparib is hazardous in pregnancy.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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