Drug interactions
Desogestrel-ethinyl estradiol + Stiripentol
Severity: Moderate
Desogestrel-ethinyl estradiol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP enzymes including CYP3A4. Its net effect on contraceptive hormone levels is unpredictable, and efficacy may be reduced.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters metabolism of ethinyl estradiol and etonogestrel.
What to do
Counsel on an additional non-hormonal contraceptive method and monitor for breakthrough bleeding. Consider a method not affected by enzyme changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Stiripentol?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP enzymes including CYP3A4. Its net effect on contraceptive hormone levels is unpredictable, and efficacy may be reduced.
How serious is the interaction between Desogestrel-ethinyl estradiol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on an additional non-hormonal contraceptive method and monitor for breakthrough bleeding. Consider a method not affected by enzyme changes.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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