Drug interactions
Desogestrel-ethinyl estradiol + Trimipramine
Severity: Minor
Desogestrel-ethinyl estradiol and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives may raise trimipramine concentrations, increasing anticholinergic, sedative and cardiac adverse effects. Evidence is limited.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Ethinyl estradiol may inhibit oxidative metabolism of tricyclic antidepressants.
What to do
Monitor for tricyclic adverse effects and reduce the trimipramine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Trimipramine?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives may raise trimipramine concentrations, increasing anticholinergic, sedative and cardiac adverse effects. Evidence is limited.
How serious is the interaction between Desogestrel-ethinyl estradiol and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and reduce the trimipramine dose if they occur.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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