Drug interactions
Desogestrel-ethinyl estradiol + Vadadustat
Severity: Moderate
Desogestrel-ethinyl estradiol and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may raise exposure to BCRP substrates, including ethinyl estradiol. Increased estrogen exposure could heighten estrogen-related adverse effects, including thrombotic risk, which is already a concern in dialysis patients taking vadadustat.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits the BCRP efflux transporter, increasing systemic exposure to ethinyl estradiol.
What to do
Monitor for estrogen-related adverse effects and consider a lower-estrogen or non-estrogen contraceptive in patients with thrombotic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Vadadustat?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and may raise exposure to BCRP substrates, including ethinyl estradiol. Increased estrogen exposure could heighten estrogen-related adverse effects, including thrombotic risk, which is already a concern in dialysis patients taking vadadustat.
How serious is the interaction between Desogestrel-ethinyl estradiol and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects and consider a lower-estrogen or non-estrogen contraceptive in patients with thrombotic risk factors.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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