Drug interactions
Desvenlafaxine + Dihydroergotamine
Severity: Moderate
Desvenlafaxine and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic receptor activity, and combining it with SNRIs such as desvenlafaxine has been associated with serotonin syndrome risk. Dihydroergotamine also causes vasoconstriction.
What this interaction means in plain words
Desvenlafaxine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity through 5-HT receptor agonism and serotonin reuptake inhibition.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, hyperreflexia and fever. Stop the serotonergic agents and give supportive care if it is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Dihydroergotamine?
MediHelp rates the interaction as moderate. Desvenlafaxine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonergic receptor activity, and combining it with SNRIs such as desvenlafaxine has been associated with serotonin syndrome risk. Dihydroergotamine also causes vasoconstriction.
How serious is the interaction between Desvenlafaxine and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, hyperreflexia and fever. Stop the serotonergic agents and give supportive care if it is suspected.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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