Drug interactions
Desvenlafaxine + Dolasetron
Severity: Moderate
Desvenlafaxine and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
5-HT3 antagonists given with serotonergic antidepressants have been linked to rare cases of serotonin syndrome. The risk with desvenlafaxine is considered low but the outcome can be serious.
What this interaction means in plain words
Desvenlafaxine and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Possible additive serotonergic activity; the mechanism for 5-HT3 antagonists is not firmly established.
What to do
Monitor for signs of serotonin toxicity such as clonus, hyperthermia, agitation and autonomic instability after starting or adding either drug. Stop both and treat supportively if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Dolasetron?
MediHelp rates the interaction as moderate. Desvenlafaxine and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. 5-HT3 antagonists given with serotonergic antidepressants have been linked to rare cases of serotonin syndrome. The risk with desvenlafaxine is considered low but the outcome can be serious.
How serious is the interaction between Desvenlafaxine and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as clonus, hyperthermia, agitation and autonomic instability after starting or adding either drug. Stop both and treat supportively if it develops.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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