Drug interactions
Desvenlafaxine + Eletriptan
Severity: Moderate
Desvenlafaxine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans combined with SNRIs have been associated with serotonin syndrome, although the incidence is low. The combination is common in patients with migraine and depression.
What this interaction means in plain words
Desvenlafaxine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from 5-HT1B/1D agonism and serotonin reuptake inhibition.
What to do
Counsel patients on the symptoms of serotonin syndrome and use the lowest effective eletriptan dose. Stop both drugs and seek care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Eletriptan?
MediHelp rates the interaction as moderate. Desvenlafaxine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans combined with SNRIs have been associated with serotonin syndrome, although the incidence is low. The combination is common in patients with migraine and depression.
How serious is the interaction between Desvenlafaxine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on the symptoms of serotonin syndrome and use the lowest effective eletriptan dose. Stop both drugs and seek care if symptoms appear.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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