Drug interactions
Desvenlafaxine + Oxycodone
Severity: Moderate
Desvenlafaxine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine weakly inhibits CYP2D6, which may slightly alter oxycodone's metabolism to oxymorphone, though the clinical impact is generally small. Both drugs are serotonergic to some degree, so serotonin syndrome is a rare concern.
What this interaction means in plain words
Desvenlafaxine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Weak CYP2D6 inhibition by desvenlafaxine plus possible additive serotonergic effects.
What to do
Monitor analgesic response and watch for serotonin toxicity symptoms such as agitation, tremor and hyperthermia; adjust oxycodone if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Oxycodone?
MediHelp rates the interaction as moderate. Desvenlafaxine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine weakly inhibits CYP2D6, which may slightly alter oxycodone's metabolism to oxymorphone, though the clinical impact is generally small. Both drugs are serotonergic to some degree, so serotonin syndrome is a rare concern.
How serious is the interaction between Desvenlafaxine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and watch for serotonin toxicity symptoms such as agitation, tremor and hyperthermia; adjust oxycodone if needed.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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