Drug interactions
Desvenlafaxine + Ozanimod
Severity: Major
Desvenlafaxine and Ozanimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, so combining it with drugs that raise serotonin or norepinephrine may risk hypertensive crisis or serotonin syndrome. Clinical data are limited, but labeling advises against the combination.
What this interaction means in plain words
Desvenlafaxine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desvenlafaxine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites, adding to SNRI augmentation of norepinephrine and serotonin.
What to do
Avoid if possible and choose a non-serotonergic alternative. If both are required, monitor blood pressure and heart rate and watch for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Ozanimod?
MediHelp rates the interaction as major. Desvenlafaxine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolites inhibit MAO-B in vitro, so combining it with drugs that raise serotonin or norepinephrine may risk hypertensive crisis or serotonin syndrome. Clinical data are limited, but labeling advises against the combination.
How serious is the interaction between Desvenlafaxine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a non-serotonergic alternative. If both are required, monitor blood pressure and heart rate and watch for serotonin toxicity.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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