Drug interactions
Desvenlafaxine + Pregabalin
Severity: Moderate
Desvenlafaxine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin commonly causes sedation and dizziness, and rarely respiratory depression in vulnerable patients. Desvenlafaxine can add to dizziness and somnolence, so psychomotor impairment is possible.
What this interaction means in plain words
Desvenlafaxine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Titrate pregabalin gradually and monitor for sedation, dizziness and respiratory depression. Warn the patient about driving and caution with opioids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Desvenlafaxine with Pregabalin?
MediHelp rates the interaction as moderate. Desvenlafaxine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin commonly causes sedation and dizziness, and rarely respiratory depression in vulnerable patients. Desvenlafaxine can add to dizziness and somnolence, so psychomotor impairment is possible.
How serious is the interaction between Desvenlafaxine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pregabalin gradually and monitor for sedation, dizziness and respiratory depression. Warn the patient about driving and caution with opioids.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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