Drug interactions
Deutetrabenazine + Dronedarone
Severity: Moderate
Deutetrabenazine and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and deutetrabenazine can cause small QT increases, mainly at higher exposures. Used together they may add to the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbances.
What this interaction means in plain words
Deutetrabenazine and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Dronedarone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and monitor QTc after starting the combination. Correct potassium and magnesium and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Dronedarone?
MediHelp rates the interaction as moderate. Deutetrabenazine and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone prolongs the QT interval and deutetrabenazine can cause small QT increases, mainly at higher exposures. Used together they may add to the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbances.
How serious is the interaction between Deutetrabenazine and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc after starting the combination. Correct potassium and magnesium and avoid other QT-prolonging drugs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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