Drug interactions
Deutetrabenazine + Fluphenazine
Severity: Moderate
Deutetrabenazine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect dopaminergic transmission, and combining them may increase parkinsonism, akathisia, sedation and the risk of neuroleptic malignant syndrome. Both may also contribute to QT prolongation, although deutetrabenazine has little effect at usual doses.
What this interaction means in plain words
Deutetrabenazine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism and depletion via D2 blockade and VMAT2 inhibition, plus additive sedation.
What to do
Monitor for worsening extrapyramidal symptoms, rigidity, fever and altered mental status. Use the lowest effective doses and consider an ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Fluphenazine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents affect dopaminergic transmission, and combining them may increase parkinsonism, akathisia, sedation and the risk of neuroleptic malignant syndrome. Both may also contribute to QT prolongation, although deutetrabenazine has little effect at usual doses.
How serious is the interaction between Deutetrabenazine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening extrapyramidal symptoms, rigidity, fever and altered mental status. Use the lowest effective doses and consider an ECG in patients with QT risk factors.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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