Drug interactions
Deutetrabenazine + Fluvoxamine
Severity: Moderate
Deutetrabenazine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some potential to prolong the QT interval, although deutetrabenazine does so only modestly at recommended doses. The risk of arrhythmia increases with other risk factors such as electrolyte disturbance or bradycardia. Fluvoxamine's CYP2D6 inhibition may also raise levels of deutetrabenazine's active metabolites.
What this interaction means in plain words
Deutetrabenazine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and fluvoxamine-related inhibition of CYP2D6 metabolism of active metabolites.
What to do
Check an ECG and electrolytes in patients with QT risk factors, and keep the deutetrabenazine dose within the labeled limit for CYP2D6 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Fluvoxamine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have some potential to prolong the QT interval, although deutetrabenazine does so only modestly at recommended doses. The risk of arrhythmia increases with other risk factors such as electrolyte disturbance or bradycardia. Fluvoxamine's CYP2D6 inhibition may also raise levels of deutetrabenazine's active metabolites.
How serious is the interaction between Deutetrabenazine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes in patients with QT risk factors, and keep the deutetrabenazine dose within the labeled limit for CYP2D6 inhibitors.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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