Drug interactions
Deutetrabenazine + Gemifloxacin
Severity: Moderate
Deutetrabenazine and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemifloxacin prolongs the QT interval, and deutetrabenazine has a small QT effect that is not usually relevant at recommended doses. The combination may still add to arrhythmia risk, mainly in patients with bradycardia, electrolyte disturbance or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Obtain a baseline ECG and correct low potassium or magnesium. Avoid the combination in patients with congenital long QT or other QT-prolonging therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Gemifloxacin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemifloxacin prolongs the QT interval, and deutetrabenazine has a small QT effect that is not usually relevant at recommended doses. The combination may still add to arrhythmia risk, mainly in patients with bradycardia, electrolyte disturbance or congenital long QT.
How serious is the interaction between Deutetrabenazine and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct low potassium or magnesium. Avoid the combination in patients with congenital long QT or other QT-prolonging therapy.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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