Drug interactions
Deutetrabenazine + Granisetron
Severity: Moderate
Deutetrabenazine and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Granisetron has a small QT-prolonging effect, and deutetrabenazine can prolong QTc modestly, mainly at higher exposures. The combination may increase torsade de pointes risk in patients with bradycardia, electrolyte abnormalities or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) by both drugs.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Avoid use in congenital long QT syndrome and monitor ECG in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Granisetron?
MediHelp rates the interaction as moderate. Deutetrabenazine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Granisetron has a small QT-prolonging effect, and deutetrabenazine can prolong QTc modestly, mainly at higher exposures. The combination may increase torsade de pointes risk in patients with bradycardia, electrolyte abnormalities or congenital long QT.
How serious is the interaction between Deutetrabenazine and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before combining. Avoid use in congenital long QT syndrome and monitor ECG in patients with other risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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