Drug interactions
Deutetrabenazine + Haloperidol
Severity: Moderate
Deutetrabenazine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce dopaminergic transmission (haloperidol by D2 blockade, deutetrabenazine by VMAT2 inhibition), so together they can increase parkinsonism, akathisia, sedation and the risk of neuroleptic malignant syndrome. Both can also affect QT interval, with haloperidol being the main contributor.
What this interaction means in plain words
Deutetrabenazine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic antidopaminergic effects from postsynaptic D2 blockade plus presynaptic dopamine depletion, with possible additive QT effects.
What to do
Monitor for extrapyramidal symptoms, sedation, hyperthermia and rigidity, and consider an ECG in patients with QT risk factors. Use the lowest effective doses of each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Haloperidol?
MediHelp rates the interaction as moderate. Deutetrabenazine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce dopaminergic transmission (haloperidol by D2 blockade, deutetrabenazine by VMAT2 inhibition), so together they can increase parkinsonism, akathisia, sedation and the risk of neuroleptic malignant syndrome. Both can also affect QT interval, with haloperidol being the main contributor.
How serious is the interaction between Deutetrabenazine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation, hyperthermia and rigidity, and consider an ECG in patients with QT risk factors. Use the lowest effective doses of each drug.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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