Drug interactions
Deutetrabenazine + Hydroxyzine
Severity: Moderate
Deutetrabenazine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine commonly causes somnolence and hydroxyzine adds to sedation. Both drugs have QT-prolonging potential, so the combination matters in patients with cardiac risk factors or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression and additive QT prolongation.
What to do
Monitor sedation and consider an ECG and electrolytes in patients with QT risk factors. Use the lowest effective hydroxyzine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Hydroxyzine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine commonly causes somnolence and hydroxyzine adds to sedation. Both drugs have QT-prolonging potential, so the combination matters in patients with cardiac risk factors or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and consider an ECG and electrolytes in patients with QT risk factors. Use the lowest effective hydroxyzine dose.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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