Drug interactions
Deutetrabenazine + Itraconazole
Severity: Moderate
Deutetrabenazine and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QTc prolongation, so combined use may add to the risk of torsades de pointes. The risk is greater with bradycardia, electrolyte disturbance or congenital long QT. Itraconazole may also raise exposure to active deutetrabenazine metabolites through CYP3A4 inhibition, though this is a minor pathway.
What this interaction means in plain words
Deutetrabenazine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QTc prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid the combination in patients with congenital long QT or other risk factors for arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Itraconazole?
MediHelp rates the interaction as moderate. Deutetrabenazine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QTc prolongation, so combined use may add to the risk of torsades de pointes. The risk is greater with bradycardia, electrolyte disturbance or congenital long QT. Itraconazole may also raise exposure to active deutetrabenazine metabolites through CYP3A4 inhibition, though this is a minor pathway.
How serious is the interaction between Deutetrabenazine and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid the combination in patients with congenital long QT or other risk factors for arrhythmia.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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