Drug interactions
Deutetrabenazine + Loperamide
Severity: Moderate
Deutetrabenazine and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some potential for QT prolongation, though deutetrabenazine has little effect at recommended doses. The risk increases with high loperamide doses, electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Possible additive QT prolongation.
What to do
Use labeled loperamide doses and correct potassium and magnesium abnormalities. Obtain an ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Loperamide?
MediHelp rates the interaction as moderate. Deutetrabenazine and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have some potential for QT prolongation, though deutetrabenazine has little effect at recommended doses. The risk increases with high loperamide doses, electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use labeled loperamide doses and correct potassium and magnesium abnormalities. Obtain an ECG in patients with additional QT risk factors.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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