Drug interactions
Deutetrabenazine + Lurasidone
Severity: Moderate
Deutetrabenazine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine depletes presynaptic monoamines and lurasidone blocks dopamine receptors, so combined use may increase parkinsonism, akathisia and the risk of neuroleptic malignant syndrome. Additive sedation and QT effects may also occur.
What this interaction means in plain words
Deutetrabenazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive antidopaminergic effects from VMAT2 inhibition and D2 receptor blockade.
What to do
Monitor for extrapyramidal symptoms, akathisia, sedation and signs of neuroleptic malignant syndrome. Adjust the deutetrabenazine dose or reassess antipsychotic therapy if movement symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Lurasidone?
MediHelp rates the interaction as moderate. Deutetrabenazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine depletes presynaptic monoamines and lurasidone blocks dopamine receptors, so combined use may increase parkinsonism, akathisia and the risk of neuroleptic malignant syndrome. Additive sedation and QT effects may also occur.
How serious is the interaction between Deutetrabenazine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia, sedation and signs of neuroleptic malignant syndrome. Adjust the deutetrabenazine dose or reassess antipsychotic therapy if movement symptoms worsen.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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