Drug interactions
Deutetrabenazine + Mefloquine
Severity: Moderate
Deutetrabenazine and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, though deutetrabenazine does so only modestly at recommended doses. Combined use adds to the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbances.
What this interaction means in plain words
Deutetrabenazine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Mefloquine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, though deutetrabenazine does so only modestly at recommended doses. Combined use adds to the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbances.
How serious is the interaction between Deutetrabenazine and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and avoid the combination in congenital long QT syndrome.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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