Drug interactions
Deutetrabenazine + Mirabegron
Severity: Moderate
Deutetrabenazine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate CYP2D6 inhibitor and can raise exposure to the active metabolites of deutetrabenazine, which are cleared by CYP2D6. Higher exposure may increase dose-related adverse effects such as sedation, depression, parkinsonism and QT prolongation.
What this interaction means in plain words
Deutetrabenazine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing metabolism of deutetrabenazine's active dihydro-metabolites.
What to do
Titrate deutetrabenazine cautiously and stay within the labeled maximum for CYP2D6 inhibitor use. Monitor for sedation, mood changes, extrapyramidal symptoms and QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Mirabegron?
MediHelp rates the interaction as moderate. Deutetrabenazine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate CYP2D6 inhibitor and can raise exposure to the active metabolites of deutetrabenazine, which are cleared by CYP2D6. Higher exposure may increase dose-related adverse effects such as sedation, depression, parkinsonism and QT prolongation.
How serious is the interaction between Deutetrabenazine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate deutetrabenazine cautiously and stay within the labeled maximum for CYP2D6 inhibitor use. Monitor for sedation, mood changes, extrapyramidal symptoms and QT effects.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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