Drug interactions
Deutetrabenazine + Moxifloxacin
Severity: Moderate
Deutetrabenazine and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin clearly prolongs the QT interval, while deutetrabenazine has a small QT effect at therapeutic doses. Combination may add to risk of torsades de pointes in patients with other risk factors such as bradycardia or electrolyte disturbances.
What this interaction means in plain words
Deutetrabenazine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization, with moxifloxacin being the main contributor.
What to do
Check ECG and correct potassium and magnesium in patients with cardiac risk factors. Choose a non-QT-prolonging antibiotic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Moxifloxacin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin clearly prolongs the QT interval, while deutetrabenazine has a small QT effect at therapeutic doses. Combination may add to risk of torsades de pointes in patients with other risk factors such as bradycardia or electrolyte disturbances.
How serious is the interaction between Deutetrabenazine and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium in patients with cardiac risk factors. Choose a non-QT-prolonging antibiotic if the QTc is prolonged.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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