Drug interactions
Deutetrabenazine + Paliperidone
Severity: Major
Deutetrabenazine and Paliperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine depletes presynaptic monoamines, and with a dopamine antagonist like paliperidone the risk of parkinsonism, akathisia, sedation and neuroleptic malignant syndrome rises. Both drugs may also contribute to QT prolongation and depression.
What this interaction means in plain words
Deutetrabenazine and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deutetrabenazine belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive dopaminergic blockade and depletion, plus additive sedative and QT effects.
What to do
Monitor for EPS, akathisia, rigidity, fever and mood changes, and consider ECG monitoring. Use the lowest effective doses and reduce either drug if movement symptoms worsen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Paliperidone?
MediHelp rates the interaction as major. Deutetrabenazine and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deutetrabenazine depletes presynaptic monoamines, and with a dopamine antagonist like paliperidone the risk of parkinsonism, akathisia, sedation and neuroleptic malignant syndrome rises. Both drugs may also contribute to QT prolongation and depression.
How serious is the interaction between Deutetrabenazine and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for EPS, akathisia, rigidity, fever and mood changes, and consider ECG monitoring. Use the lowest effective doses and reduce either drug if movement symptoms worsen.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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