Drug interactions
Deutetrabenazine + Solifenacin
Severity: Moderate
Deutetrabenazine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin has a dose-related potential to prolong the QT interval, and deutetrabenazine may add a small effect at higher exposures. The risk matters mainly in patients with other torsade risk factors.
What this interaction means in plain words
Deutetrabenazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation through cardiac repolarization effects.
What to do
Check baseline ECG and correct potassium and magnesium in patients with risk factors; avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Solifenacin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin has a dose-related potential to prolong the QT interval, and deutetrabenazine may add a small effect at higher exposures. The risk matters mainly in patients with other torsade risk factors.
How serious is the interaction between Deutetrabenazine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium in patients with risk factors; avoid the combination in congenital long QT syndrome.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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