Drug interactions
Deutetrabenazine + Voriconazole
Severity: Moderate
Deutetrabenazine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole prolongs the QT interval, and deutetrabenazine can cause small QT increases, especially at higher exposures. Together they may increase the risk of arrhythmia in patients with other risk factors.
What this interaction means in plain words
Deutetrabenazine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QTc prolongation; voriconazole also inhibits CYP3A4, though deutetrabenazine's active metabolites are mainly CYP2D6 substrates.
What to do
Obtain an ECG in patients with bradycardia, electrolyte disturbances or congenital long QT, and correct electrolytes. Keep the deutetrabenazine dose within labeled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deutetrabenazine and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Voriconazole?
MediHelp rates the interaction as moderate. Deutetrabenazine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole prolongs the QT interval, and deutetrabenazine can cause small QT increases, especially at higher exposures. Together they may increase the risk of arrhythmia in patients with other risk factors.
How serious is the interaction between Deutetrabenazine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with bradycardia, electrolyte disturbances or congenital long QT, and correct electrolytes. Keep the deutetrabenazine dose within labeled limits.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
