Drug interactions
Dexamethasone + Esomeprazole
Severity: Minor
Dexamethasone and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is an inducer of CYP3A4 and possibly CYP2C19, which may lower esomeprazole concentrations. The effect is probably small given esomeprazole's wide margin of efficacy.
What this interaction means in plain words
Dexamethasone and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Dexamethasone-mediated induction of hepatic CYP enzymes may increase esomeprazole clearance.
What to do
No routine adjustment is needed. Reassess acid suppression if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Esomeprazole?
MediHelp rates the interaction as minor. Dexamethasone and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is an inducer of CYP3A4 and possibly CYP2C19, which may lower esomeprazole concentrations. The effect is probably small given esomeprazole's wide margin of efficacy.
How serious is the interaction between Dexamethasone and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess acid suppression if symptoms persist.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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