Drug interactions
Dexamethasone + Everolimus
Severity: Moderate
Dexamethasone and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may reduce everolimus concentrations through enzyme induction, potentially weakening its immunosuppressive or antineoplastic effect. The magnitude is generally modest compared with strong inducers.
What this interaction means in plain words
Dexamethasone and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Everolimus belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4 and possibly P-glycoprotein, increasing everolimus clearance.
What to do
Monitor everolimus trough levels in transplant patients and clinical response in oncology patients when dexamethasone is started or stopped. Adjust the everolimus dose based on levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Everolimus?
MediHelp rates the interaction as moderate. Dexamethasone and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may reduce everolimus concentrations through enzyme induction, potentially weakening its immunosuppressive or antineoplastic effect. The magnitude is generally modest compared with strong inducers.
How serious is the interaction between Dexamethasone and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels in transplant patients and clinical response in oncology patients when dexamethasone is started or stopped. Adjust the everolimus dose based on levels.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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