Drug interactions
Dexamethasone + Fedratinib
Severity: Moderate
Dexamethasone and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may raise dexamethasone concentrations, increasing the risk of corticosteroid adverse effects. The clinical impact is likely modest with short courses.
What this interaction means in plain words
Dexamethasone and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Fedratinib belongs to Oncology.
Why it happens
Fedratinib is a moderate CYP3A4 inhibitor that reduces the metabolic clearance of dexamethasone.
What to do
Monitor for steroid adverse effects such as hyperglycemia, fluid retention and infection, and reduce the dexamethasone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Dexamethasone with Fedratinib?
MediHelp rates the interaction as moderate. Dexamethasone and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may raise dexamethasone concentrations, increasing the risk of corticosteroid adverse effects. The clinical impact is likely modest with short courses.
How serious is the interaction between Dexamethasone and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for steroid adverse effects such as hyperglycemia, fluid retention and infection, and reduce the dexamethasone dose if they occur.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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