Drug interactions
Dexamethasone + Fluconazole
Severity: Moderate
Dexamethasone and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is metabolized by CYP3A4, and fluconazole may modestly raise its exposure. Systemic corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression may be increased, particularly with prolonged use.
What this interaction means in plain words
Dexamethasone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, reducing dexamethasone clearance.
What to do
Monitor for corticosteroid excess, including blood glucose and blood pressure. Lower the dexamethasone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Fluconazole?
MediHelp rates the interaction as moderate. Dexamethasone and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is metabolized by CYP3A4, and fluconazole may modestly raise its exposure. Systemic corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression may be increased, particularly with prolonged use.
How serious is the interaction between Dexamethasone and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess, including blood glucose and blood pressure. Lower the dexamethasone dose if adverse effects appear.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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