Drug interactions
Dexamethasone + Temsirolimus
Severity: Moderate
Dexamethasone and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so dexamethasone induction may lower exposure. Reduced antitumor effect is possible, particularly with sustained steroid use.
What this interaction means in plain words
Dexamethasone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing temsirolimus and sirolimus metabolism.
What to do
Monitor treatment response; avoid prolonged high-dose steroid when alternatives exist. A temsirolimus dose increase is advised only with strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Dexamethasone with Temsirolimus?
MediHelp rates the interaction as moderate. Dexamethasone and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so dexamethasone induction may lower exposure. Reduced antitumor effect is possible, particularly with sustained steroid use.
How serious is the interaction between Dexamethasone and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response; avoid prolonged high-dose steroid when alternatives exist. A temsirolimus dose increase is advised only with strong inducers.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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