Drug interactions
Dexamethasone + Vortioxetine
Severity: Minor
Dexamethasone and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce CYP enzymes and may lower vortioxetine concentrations, especially with prolonged use. Reduced antidepressant effect is possible, but dexamethasone is only a modest inducer.
What this interaction means in plain words
Dexamethasone and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Vortioxetine belongs to Central Nervous System.
Why it happens
Induction of hepatic CYP enzymes by dexamethasone increases vortioxetine clearance.
What to do
Monitor depressive symptoms during prolonged dexamethasone therapy and consider increasing the vortioxetine dose if response wanes, within the labeled maximum.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Vortioxetine?
MediHelp rates the interaction as minor. Dexamethasone and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone can induce CYP enzymes and may lower vortioxetine concentrations, especially with prolonged use. Reduced antidepressant effect is possible, but dexamethasone is only a modest inducer.
How serious is the interaction between Dexamethasone and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms during prolonged dexamethasone therapy and consider increasing the vortioxetine dose if response wanes, within the labeled maximum.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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