Drug interactions
Dexamethasone-neomycin-polymyxin + Erythromycin lactobionate
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise dexamethasone exposure, while dexamethasone may induce CYP3A4 and lower erythromycin levels. The systemic effect is limited when dexamethasone is given as a topical or ophthalmic combination, but corticosteroid excess is possible with systemic use.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4-mediated dexamethasone metabolism, and dexamethasone is a weak-to-moderate CYP3A4 inducer.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression if systemic dexamethasone is used. Check that the antibiotic response remains adequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise dexamethasone exposure, while dexamethasone may induce CYP3A4 and lower erythromycin levels. The systemic effect is limited when dexamethasone is given as a topical or ophthalmic combination, but corticosteroid excess is possible with systemic use.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression if systemic dexamethasone is used. Check that the antibiotic response remains adequate.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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