Drug interactions
Dexamethasone-neomycin-polymyxin + Fedratinib
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may increase dexamethasone exposure, which could heighten corticosteroid adverse effects. The effect is clinically relevant mainly with systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing dexamethasone metabolism.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and mood changes. Reduce the dexamethasone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Fedratinib?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may increase dexamethasone exposure, which could heighten corticosteroid adverse effects. The effect is clinically relevant mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and mood changes. Reduce the dexamethasone dose if they occur.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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