Drug interactions
Dexamethasone-neomycin-polymyxin + Fostamatinib
Severity: Minor
Dexamethasone-neomycin-polymyxin and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as dexamethasone. The clinical effect is likely small and relevant mainly with systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein increases dexamethasone absorption.
What to do
Monitor for corticosteroid adverse effects with systemic dexamethasone. Reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Fostamatinib?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as dexamethasone. The clinical effect is likely small and relevant mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects with systemic dexamethasone. Reduce the dose if they occur.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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