Drug interactions
Dexamethasone-neomycin-polymyxin + Lopinavir
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and can raise dexamethasone levels, while dexamethasone may induce CYP3A4 and lower lopinavir exposure. Combined systemic use may cause steroid excess and possibly reduce antiviral efficacy. Topical use of this product gives limited systemic exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lopinavir belongs to Anti Virals.
Why it happens
Bidirectional CYP3A4 effects: ritonavir-boosted lopinavir inhibits dexamethasone metabolism, and dexamethasone induces CYP3A4.
What to do
Short topical courses need no change. With systemic or prolonged use, monitor for Cushingoid effects and HIV viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lopinavir?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 and can raise dexamethasone levels, while dexamethasone may induce CYP3A4 and lower lopinavir exposure. Combined systemic use may cause steroid excess and possibly reduce antiviral efficacy. Topical use of this product gives limited systemic exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short topical courses need no change. With systemic or prolonged use, monitor for Cushingoid effects and HIV viral load.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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