Drug interactions
Dexamethasone-neomycin-polymyxin + Methylprednisolone
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two systemic corticosteroids give duplicate therapy with additive adverse effects. Dexamethasone may also induce CYP3A4 and slightly reduce methylprednisolone exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Methylprednisolone belongs to Endocrine.
Why it happens
Additive glucocorticoid pharmacodynamics with possible CYP3A4 induction by dexamethasone.
What to do
Avoid concurrent use of two corticosteroids unless intended. Monitor glucose, blood pressure and signs of corticosteroid excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Methylprednisolone?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two systemic corticosteroids give duplicate therapy with additive adverse effects. Dexamethasone may also induce CYP3A4 and slightly reduce methylprednisolone exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two corticosteroids unless intended. Monitor glucose, blood pressure and signs of corticosteroid excess.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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