Drug interactions
Dexamethasone-neomycin-polymyxin + Nevirapine
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower dexamethasone exposure. Dexamethasone may in turn lower nevirapine levels, risking reduced antiviral efficacy.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Nevirapine belongs to Anti Virals.
Why it happens
Mutual CYP3A4 induction accelerates metabolism of both drugs.
What to do
Monitor clinical response to dexamethasone and HIV viral load during prolonged systemic use. Adjust the corticosteroid dose if effect is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Nevirapine?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower dexamethasone exposure. Dexamethasone may in turn lower nevirapine levels, risking reduced antiviral efficacy.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dexamethasone and HIV viral load during prolonged systemic use. Adjust the corticosteroid dose if effect is reduced.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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