Drug interactions
Dexamethasone-neomycin-polymyxin + Oxycodone
Severity: Minor
Dexamethasone-neomycin-polymyxin and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and reduce oxycodone concentrations, possibly decreasing analgesia. Stopping dexamethasone could later raise oxycodone levels.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Oxycodone belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by dexamethasone increases oxycodone metabolism.
What to do
Monitor pain control and adjust oxycodone dose if systemic dexamethasone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Oxycodone?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and reduce oxycodone concentrations, possibly decreasing analgesia. Stopping dexamethasone could later raise oxycodone levels.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and adjust oxycodone dose if systemic dexamethasone is started or stopped.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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