Drug interactions
Dexamethasone-tobramycin + Enzalutamide
Severity: Moderate
Dexamethasone-tobramycin and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and lowers systemic dexamethasone exposure, possibly reducing its efficacy. Dexamethasone is also a CYP3A4 substrate that can be used with enzalutamide in prostate cancer. Relevance is greatest with systemic dosing.
What this interaction means in plain words
Dexamethasone-tobramycin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induction of CYP3A4 accelerates dexamethasone metabolism.
What to do
With systemic dexamethasone, monitor clinical response and increase the dose if effect is inadequate. No action is needed for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Enzalutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Enzalutamide?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and lowers systemic dexamethasone exposure, possibly reducing its efficacy. Dexamethasone is also a CYP3A4 substrate that can be used with enzalutamide in prostate cancer. Relevance is greatest with systemic dosing.
How serious is the interaction between Dexamethasone-tobramycin and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor clinical response and increase the dose if effect is inadequate. No action is needed for topical use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
